Parkinsonism and dementia with acoustic neurinomas

Summary Three cases of acoustic neurinoma with parkinsonism and dementia are reported. The characteristics of parkinsonism seen in these cases consisted of the rapid development of symptoms and symmetrical rigidity. In all cases there was a marked enlargement of the ventricular system and transient improvement in their mental states was observed following ventriculoperitoneal shunt or removal of the tumor. In an autopsy case there were no pathological findings in the cerebral cortex, basal ganglia, substantia nigra or pontine nuclei. It was concluded that parkinsonism and dementia in these patients were caused by chronic hydrocephalus due to the acoustic neurinomas.

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Zusammenfassung Es wird über drei Fälle von Akustikusneurinom mit begleitenden Symptomen eines Parkinsonismus und einer Demenz berichtet. Diese Symptome wurden als Ausdruck eines chronischen Hydrocephalus betrachtet und in ihren klinischen Besonderheiten im einzelnen dargelegt.

     

子宫内膜异位症对绝经后妇女亚临床脑血管病及认知功能的影响

目的 比较是否有子宫内膜异位症(EMT)病史的绝经后妇女亚临床脑血管病及认知功能的差异,探讨EMT对亚临床脑血管及认知功能的远期影响及机制。方法 回顾性选择2018年5月至2020年8月东部战区总医院妇产科门诊及住院治疗的154例患者,根据有无EMT病史将绝经后患者分为EMT组(77例)和对照组(77例)。采用头颅核磁共振血管成像检查脑白质损害(WML)、腔隙性脑梗死及颅内血管狭窄,颈部超声检查颈部血管斑块,评估2组患者的认知功能。采用SPSS 22.0统计软件进行数据分析。采用χ²检验或配对t检验进行组间比较;采用logistic回归分析绝经妇女发生颈动脉斑块及WML的风险因素。 结果 EMT组与对照组WML分别为40.3%(31/77)和22.1%(17/77)(P＜0.05)及颈动脉斑块分别为36.4%(28/77)和19.5%(15/77)(P＜0.05)。logistic回归显示,调整年龄、高血压、血脂异常后,EMT是WML(OR= 3.041, 95%CI 1.405~6.586)和颈动脉斑块(OR =2.971, 95%CI 1.340~6.483 )发生的危险因素(P＜0.05)。EMT组患者的词语学习、符号数字及动物流畅测试评分较对照组显著降低(P＜0.05)。结论 EMT是绝经后妇女发生WML及颈动脉斑块的风险因素,对女性亚临床脑血管病及认知功能具有远期影响。